· 基本信息
刘国君，男，蒙古族，1989年7月，内蒙古通辽市人
博士 讲师
办公地址：必赢bwin线路检测中心腾飞楼A509
联系方式：gjliu77@qq.com
· 教育经历
(1) 2015-09至2019-06, 乌拉尔联邦大学, 生物学, 哲学博士
(2) 2012-09至2015-06, 内蒙古大学, 生物物理学, 理学硕士
(3) 2007-09至2011-06, 内蒙古师范大学, 物理学, 理学学士
· 科研与学术工作经历
(1) 2020-09至现在, 必赢线路检测3003no1, 必赢bwin线路检测中心, 讲师
(2) 2019-09至2020-09, 俄罗斯乌拉尔联邦大学, 自然科学与数学学院, 助理研究员
· 研究方向
肿瘤与免疫疾病相关生物信息学研究，包括肿瘤亚型预测、基因调控网络构建、数据库搭建、服务器与软件开发
· 教学情况
主讲《组学理论及数据分析》、《组学数据分析实战》、《高级程序语言实战》、《生物信息学软件应用》、《基因组学》及《认识实习》等课程。
· 科研项目
1) 内蒙古自然科学基金项目，联合青年，2022LHQN03005，基于多组学数据挖掘的肿瘤脂质代谢途径的研究，2022.1至2024.12，8万元，在研，主持
2) 必赢线路检测3003no1科研启动专项项目，0303052205， 2022.6至2025.6，5万元，在研，主持
3) 国家自然科学基金委员会, 重点项目, 62231013, 面向环状RNA的深度挖掘分析与功能研究, 2023-01- 01 至 2027-12-31, 274万元, 在研, 参与
4) 国家自然科学基金委员会，地区项目，62161039，整合多组学数据识别小鼠原肠运动中的pre-mRNA可变剪接事件及其功能分析，2022.1至2025.12，35万，在研，参与
5) 国家自然科学基金委员会，地区项目，62161043，局部染色质结构的数理建模与特征分析，2022.1至2025.12，39万元，在研，参与
· 获奖与荣誉
1) 内蒙古自治区大学生生命科学竞赛（2022，科学探究类），一等奖，第二指导教师
2) 全国大学生生命科学竞赛（2022，科学探究类），一等奖，第二指导教师
3) 必赢线路检测3003no1第七届“互联网+”大学生创新创业大赛，2021，优秀奖，第二指导教师
4) 2015-2019俄罗斯政府奖学金，the Act 211 Government of the Russian Federation (No. 02.A03.21.0006)，the IIP UB RAS project (No. AAAA- A18-118020590108-7).
· 代表性论著（包括论文与专著，#共一，*通讯）
(1) Shinwari, K., Rehman, H. M., Xiao, N., Guojun, L., Khan, M. A., Bolkov, M. A., Chereshnev, V. A. (2023). Novel high-risk missense mutations identification in FAT4 gene causing Hennekam syndrome and Van Maldergem syndrome 2 through molecular dynamics simulation. Informatics in Medicine Unlocked, 101160.
(2) Shinwari, Khyber, Zihao Chen, Guojun Liu*, Lu Chen, Mikhail A. Bolkov, Irina A. Tuzankina, and Valery A. Chereshnev. "Identification of The Immune Subtype Among Muscle-invasive Bladder Cancer Patients by Multiple Datasets." Acta Medica Indonesiana, 54, no. 1 (2022): 62.
(3) Shinwari, Khyber, Mikhail A. Bolkov, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, and Valery Chereshnev. "In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosomal Dominant Severe Congenital Neutropenia 1 and Cyclic Hematopoiesis." The Scientific World Journal 2022 (2022).
(4) Shinwari, Khyber, Hafiz Muzzammel Rehman, Guojun Liu, Mikhail A. Bolkov, Irina A. Tuzankina, and Valery A. Chereshnev. "Novel Disease-Associated Missense Single-Nucleotide Polymorphisms Variants Predication by Algorithms Tools and Molecular Dynamics Simulation of Human TCIRG1 Gene Causing Congenital Neutropenia and Osteopetrosis." Frontiers in molecular biosciences 9 (2022).
(5) Guojun Liu, Mikhail A. Bolkov, Khyber Shinwari, Irina A. Tuzankina, Valery A. Chereshnev. Prognostic and Immunotherapeutic Significance of Tumor- infiltrating M2 Macrophages in Muscle-invasive Bladder Cancer [J]. AIP Conference Proceedings, 2022.
(6) Shinwari, Khyber, Guojun Liu, Mikhail A. Bolkov, Irina A. Tuzankina, and Valery A. Chereshnev. "Gene expression and pathway analysis in patients with inborn error of TLRs and IL-IRs signaling using microarray data." In AIP Conference Proceedings, vol. 2390, no. 1, p. 030088. AIP Publishing LLC, 2022.
(7) Shinwari, Khyber, Guojun Liu, Mikhail A. Bolkov, Irina A. Tuzankina, and Valery A. Chereshnev. "Checking gene expression profile associated with IRF7 and UNC93B deficient patient peripheral blood mononuclear cells infected with pH1N1 influenza virus." In AIP Conference Proceedings, vol. 2390, no. 1, p. 030089. AIP Publishing LLC, 2022.
(8) Zihao Chen, Guojun Liu*, Guoqing Liu, Mikhail A. Bolkov, Irina A. Tuzankina, Valery A. Chereshnev, Zhifeng Wang. Defining muscle-invasive bladder cancer immunotypes by introducing tumor mutation burden, CD8+ T cells, and molecular subtypes [J]. Hereditas, 2021, 158(1),1-12
(9) Guoqing Liu, Shuangjian Song, Qiguo Zhang, Biyu Dong, Yu Sun, Guojun Liu, Xiujuan Zhao. Epigenetic Marks and Variation of Sequence-Based Information Along Genomic Regions Are Predictive of Recombination Hot/Cold Spots in Saccharomyces cerevisiae. Frontiers in Genetics [J]. 2021, 12, 1129.
(10) Khyber Shinwari, Guojun Liu, Mikhail Bolkov, Monib Ullah, Irina Tuzankina. Identifying Main Genes and Pathways by Using Gene Expression Profiling in Primary Immunodeficiency HOIL-1/RBCK1 Disorder Patients [J]. Acta Medica Iranica, 2021, 59, 5.
(11) Khyber Shinwari, Liu Guojun, Svetlana S. Deryabina, Mikhail A. Bolkov, Irina A. Tuzankina, Valery A. Chereshnev. Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis. The Scientific World Journal, 2021.
(12) Khyber Shinwari, Guojun Liu, Mikhail A. Bolkov, Izaz Ahmad, Muhmmad Daud, Irina A. Tuzankina, Valery. A. Chereshnev. Is up-regulation gene expression of the certain genes during the viral respiratory tract infection would have any influence in pathogenesis of the SAR-CoV-2 infection? [J]. Acta Medica Iranica, 2020, 246-248.
(13) G Liu, G Liu, X Cui, Y Xu. "Transcriptomic Data Analyses Reveal a Reprogramed Lipid Metabolism in HCV-Derived Hepatocellular Cancer. Frontiers in cell and developmental biology [J]. 2020, 8, 940.
(14) Guojun L., Bolkov M., Tuzankina I. Novel variation of FAT4: warty formations on the skin of the palm in mild case of Hennekam syndrome. European journal of immunology, 2019, 49, 1228-1229.
(15) Liu, G., Liu, G.J., Tan, J.X. and Lin, H., 2018. DNA physical properties outperform sequence compositional information in classifying nucleosome-enriched and-depleted regions [J]. Genomics, 2019, 111 (5), 1167-1175.
(16) МА Болков, Л Гоцзюнь, ИА Тузанкина, ИГ Данилова. Функциональные взаимоотношения между генами общей вариабельной иммунной недостаточностив геноме человека [J]. Российский журнал детской гематологии и онкологии. 2019, 6 (1), 47.
(17) Liu G, Bolkov MA, Tuzankina IA, Danilova IG. Identification of candidate disease genes in patients with common variable immunodeficiency [J]. Quantitative Biology, 2019, 7 (3), 190-201.
(18) Chen, Z., Liu, G.#, Hossain, A., Danilova, I.G., Bolkov, M.A., Liu, G., Tuzankina, I.A. and Tan, W., 2019. A co-expression network for differentially expressed genes in bladder cancer and a risk score model for predicting survival [J]. Hereditas, 2019, 156(1), 24.
(19) Guojun, L., Bolkov, M. and Tuzankina, И.А., 2019. A novel mutation in FAT4 caused a mild form of Hennekam syndrome with warty formations. European journal of immunology, 2019, 49, pp.1228-1229.
(20) Liu G, Chen Z, Danilova IG, Bolkov MA, Tuzankina IA, Liu G. Identification of miR-200c and miR141-mediated lncRNA-mRNA crosstalks in muscle-invasive bladder cancer subtypes [J]. Frontiers in genetics, 2018, 9, 422.
